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  2. Here’s How to Know If Your Metformin Is Working or Not - AOL

    www.aol.com/know-metformin-working-not-164200860...

    “It has been shown to lower the risk of death from cardiovascular disease in patients with T2DM.” ... Metformin does not cause kidney damage by itself, however there is a risk of serious side ...

  3. Rhabdomyolysis - Wikipedia

    en.wikipedia.org/wiki/Rhabdomyolysis

    [12] [32] [33] Myoglobin was demonstrated in the urine of victims by spectroscopy, and it was noted that the kidneys of victims resembled those of patients who had hemoglobinuria (hemoglobin rather than myoglobin being the cause of the kidney damage). In 1944 Bywaters demonstrated experimentally that the kidney failure was mainly caused by ...

  4. Metformin - Wikipedia

    en.wikipedia.org/wiki/Metformin

    The US Food and Drug Administration (FDA) recommends avoiding the use of metformin in more severe chronic kidney disease, below the eGFR cutoff of 30 mL/minute/1.73 m 2. [94] Lactate uptake by the liver is diminished with metformin use because lactate is a substrate for hepatic gluconeogenesis, a process that metformin inhibits.

  5. Kidney failure - Wikipedia

    en.wikipedia.org/wiki/Kidney_failure

    Acute kidney injuries can be present on top of chronic kidney disease, a condition called acute-on-chronic kidney failure (AoCRF). The acute part of AoCRF may be reversible, and the goal of treatment, as with AKI, is to return the person to baseline kidney function, typically measured by serum creatinine .

  6. Multiple organ dysfunction syndrome - Wikipedia

    en.wikipedia.org/wiki/Multiple_organ_dysfunction...

    A definite explanation has not been found. Local and systemic responses are initiated by tissue damage. Respiratory failure is common in the first 72 hours. Subsequently, one might see liver failure (5–7 days), gastrointestinal bleeding (10–15 days) and kidney failure (11–17 days). [1]

  7. Acute tubular necrosis - Wikipedia

    en.wikipedia.org/wiki/Acute_tubular_necrosis

    Damage from oxygen radicals, inflammatory cells and molecules, edema, and other mechanisms mean that when oxygen flow is restored to the tissue, it can cause further damage to the kidney, potentially worsening prognosis. Despite this risk, the return of blood flow to the tissue is necessary for its survival, so clinical strategies focus on ...

  8. Nephrotic syndrome - Wikipedia

    en.wikipedia.org/wiki/Nephrotic_syndrome

    The treatment of kidney damage may reverse or delay the progression of the disease. [44] Kidney damage is treated by prescribing drugs: Corticosteroids : the result is a decrease in proteinuria and the risk of infection as well as a resolution of the edema.

  9. Chronic kidney disease - Wikipedia

    en.wikipedia.org/wiki/Chronic_kidney_disease

    The term "non-dialysis-dependent chronic kidney disease" (NDD-CKD) is a designation used to encompass the status of those persons with an established CKD who do not yet require the life-supporting treatments for kidney failure known as kidney replacement therapy (RRT, including maintenance dialysis or kidney transplantation).

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