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Micrograph highlighting the sustentacular cells in a paraganglioma. S100 immunostain. A sustentacular cell is a type of cell primarily associated with structural support, they can be found in various tissues.
A paraganglioma is a rare neuroendocrine neoplasm that may develop at various body sites (including the head, neck, thorax and abdomen). When the same type of tumor is found in the adrenal gland, they are referred to as a pheochromocytoma .
The S100 proteins are a family of low molecular-weight proteins found in vertebrates characterized by two calcium-binding sites that have helix-loop-helix ("EF-hand-type") conformation. At least 21 different S100 proteins are known. [1] They are encoded by a family of genes whose symbols use the S100 prefix, for example, S100A1, S100A2, S100A3.
A gangliocytic paraganglioma is a rare tumour that is typically found in the duodenum and consists of three components: (1) ganglion cells, (2) epithelioid cells (paraganglioma-like) and, (3) spindle cells (schwannoma-like).
It can be the source of paraganglioma. [8]The organ of Zuckerkandl is of pathological significance in the adult as a common extra-adrenal site of pheochromocytoma though the most common extra-adrenal site is in the superior para-aortic region between the diaphragm and lower renal poles.
Lifespan or life span may refer to: Lifespan, 1976 film starring Klaus Kinski; Lifespan, 1983 Atari 8-bit computer game; Lifespan, 2004 album by Kris Davis; Lifespan: Why We Age - and Why We Don't Have To, 2019 book by David Andrew Sinclair; Lifespan.io, non-profit crowdfunding platform of the Lifespan Extension Advocacy Foundation
S100 calcium-binding protein A8 (S100A8) is a protein that in humans is encoded by the S100A8 gene. [5] It is also known as calgranulin A. The proteins S100A8 and S100A9 form a heterodimer called calprotectin. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins ...
S100 calcium-binding protein A10 (S100A10), also known as p11, is a protein [5] that is encoded by the S100A10 gene in humans and the S100a10 gene in other species. [6] [7] S100A10 is a member of the S100 family of proteins containing two EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range ...