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Madin-Darby canine kidney (MDCK) cells are a model mammalian cell line used in biomedical research. MDCK cells are used for a wide variety of cell biology studies including cell polarity , cell-cell adhesions (termed adherens junctions ), collective cell motility, toxicity studies, [ 1 ] as well as responses to growth factors.
In most cases of acute tubulointerstitial nephritis, the function of the kidneys will return after the harmful drug is discontinued, or when the underlying disease is cured by treatment. If the illness is caused by an allergic reaction, a corticosteroid may speed the recovery kidney function; however, this is often not the case.
Kidney disease When the kidneys aren’t working properly, they lose the ability to concentrate urine effectively. This causes frequent urination as the body tries to flush out toxins and maintain ...
Samoyeds can be affected by basement membrane disease of the kidneys. It is inherited through the X chromosome and is therefore more severe in affected male dogs. Findings in male dogs include the presence of protein and glucose in the urine and the inability to concentrate urine, and progression to kidney failure by the age of 9 months and death by 16 months. [3]
The disease has been shown to be a model for Alport syndrome in humans [1] in that the disease resembles that of the human disease. Because of this, it is sometimes referred to by the name given to the disease in humans when referring to the conditions in Samoyed dogs. Alternatively, it may also be known as X-linked hereditary nephritis.
For kidney involvement, the most common sequela is lymphocytic interstitial nephropathy which occurs in approximately 6%-8% of patients with DILS. The severity and presentation are varied but include acute kidney injury, renal tubular acidosis, mild proteinuria, hematuria (blood in the urine), or nephromegaly (kidney enlargement). [1] [3] [4]
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