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AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming ...
AMPK, as a cellular energy sensor, is activated by decreasing levels of ATP, which is naturally accompanied by increasing levels of ADP and AMP. [ 9 ] Though phosphorylation appears to be the main activator for AMPK, some studies suggest that AMP is an allosteric regulator as well as a direct agonist for AMPK. [ 10 ]
AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase ( HMGCR ), key enzymes involved in regulating de novo biosynthesis of fatty acid ...
The STK11/LKB1 gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumour suppressor.. LKB1 is a primary upstream kinase of adenosine monophosphate-activated protein kinase (), a necessary element in cell metabolism that is required for maintaining energy homeostasis.
AMPK may refer to: AMP-activated protein kinase, an enzyme (acetyl-CoA carboxylase) kinase, an enzyme This page was last edited on 15 May 2022, at ...
AICAR is an analog of adenosine monophosphate (AMP) that is capable of stimulating AMP-dependent protein kinase (AMPK) activity. The drug has also been shown as a potential treatment for diabetes by increasing the metabolic activity of tissues by changing the physical composition of muscle.
From the verb bokeru 惚ける or 呆ける, which carries the meaning of "senility" or "air headed-ness," and is reflected in a performer's tendency for misinterpretation and forgetfulness. The boke is the "simple-minded" member of an owarai kombi ( "tsukkomi and boke" , or vice versa ) that receives most of the verbal and physical abuse from ...
It is a general term for devils, demons and evil beings. In Japanese polytheism, it is an antonym of 神族 (shinzoku), "the tribe of gods". A maō is a king or ruler over mazoku. For instance, in Bible translations, Satan is a maō. In polytheism, the counterpart of maō is 神王 (shin'ō), "the king of gods".