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Bisphosphonates are a class of drugs that prevent the loss of bone density, used to treat osteoporosis and similar diseases. They are the most commonly prescribed drugs used to treat osteoporosis. [1] They are called bisphosphonates because they have two phosphonate (PO(OH) 2) groups. They are thus also called diphosphonates (bis-or di ...
The Agency recommended that doctors who prescribe bisphosphonate-containing medicines should be aware that atypical fractures may occur rarely in the femur, especially after long-term use, and that doctors who are prescribing these medicines for the prevention or treatment of osteoporosis should regularly review the need for continued treatment ...
Nitrogen containing bisphosphonates are the current most used drugs in the class because of their potency. [15] Studies have showed that nitrogen on bisphosphonates forms hydrogen bond with threonine (Thr201) and the carbonyl part of Lysine (Lys200) on target enzyme, therefore enhancing the binding of the complex. Altering the position of ...
If you have osteoporosis, your doctor may prescribe medicine to prevent more bone loss or build new bone mass. The most common types of medicine to prevent or treat osteoporosis include ...
When on treatment with bisphosphonates rechecking bone mineral density is not needed. [171] There is tentative evidence of benefit in males with osteoporosis. [175] Fluoride supplementation does not appear to be effective in postmenopausal osteoporosis, as even though it increases bone density, it does not decrease the risk of fractures. [176 ...
Additionally, Castelli says you’ll need to be mindful of possible interactions if you’re taking the following prescribed medications: Antibiotics like tetracycline, doxycycline, penicillin ...
Alendronic acid, sold under the brand name Fosamax among others, is a bisphosphonate medication used to treat osteoporosis and Paget's disease of bone. [4] It is taken by mouth. [4] Use is often recommended together with vitamin D, calcium supplementation, and lifestyle changes. [4]
Like methadone, Suboxone blocks both the effects of heroin withdrawal and an addict’s craving and, if used properly, does it without causing intoxication. Unlike methadone, it can be prescribed by a certified family physician and taken at home, meaning a recovering addict can lead a normal life, without a daily early-morning commute to a clinic.