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Dibenzo-1,4-dioxin, also dibenzodioxin or dibenzo-p-dioxin (dibenzo-para-dioxin), is a polycyclic heterocyclic organic compound in which two benzene rings are connected by a 1,4-dioxin ring. Its molecular formula is C 12 H 8 O 2. The two oxygen atoms occupy opposite (para-) positions in the six-membered dioxin ring.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a polychlorinated dibenzo-p-dioxin (sometimes shortened, though inaccurately, to simply 'dioxin') [3] with the chemical formula C 12 H 4 Cl 4 O 2. Pure TCDD is a colorless solid with no distinguishable odor at room temperature.
They are commonly but inaccurately referred to as dioxins for simplicity, because every PCDD molecule contains a dibenzo-1,4-dioxin skeletal structure, with 1,4-dioxin as the central ring. Members of the PCDD family bioaccumulate in humans and wildlife because of their lipophilic properties, and may cause developmental disturbances and cancer .
[2] [3] For general population the most important source is food of animal origin like with other dioxin-like compounds. [ 4 ] [ 5 ] [ 6 ] The most relevant congener is 2,3,4,7,8-pentachlorodibenzofuran (2,3,4,7,8-PCDF) which is more toxic and based on relative toxicity more prevalent than other PCDFs.
(for details see Dioxins and dioxin-like compounds). Chlorinated pesticides can also contain impurities of dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and their precursors. "Precursor formation of PCDD/Fs can also be mediated by ultraviolet light (UV)" from sun (OCDD mostly). Changes in congeners ratio after UV exposition suggest that ...
1,4-Dioxin (also referred as dioxin or p-dioxin) is a heterocyclic, organic, non-aromatic [2] compound with the chemical formula C 4 H 4 O 2. There is an isomeric form of 1,4-dioxin, 1,2-dioxin (or o -dioxin). 1,2-Dioxin is very unstable due to its peroxide -like characteristics.
With fellow weight loss medication Wegovy in short supply, it's fueling even more interest in Zepbound, Dr. Shah says. Jamie Alan, Ph.D., an associate professor of pharmacology and toxicology at ...
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