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The first medical use of fumaric acid was described in 1959 by Walter Schweckendiek, a German chemist, [15] and was a topical formulation for psoriasis. The Swiss company Fumapharm eventually brought Fumaderm, an oral formulation of dimethyl fumarate (along with some monoesters) to market for psoriasis in Germany in 1994. [16] [17] [18]
Fumaric acid was developed as a medicine to treat the autoimmune condition psoriasis in the 1950s in Germany as a tablet containing 3 esters, primarily dimethyl fumarate, and marketed as Fumaderm by Biogen Idec in Europe. Biogen would later go on to develop the main ester, dimethyl fumarate, as a treatment for multiple sclerosis.
Kircik LH, Kumar S (Aug 2010). "Scalp psoriasis". review. Journal of Drugs in Dermatology. 9 (8 Suppl ODAC Conf Pt 2): s101–5. PMID 20715392. Menter MA, Caveney SW, Gottschalk RW (Nov 2012). "Impact of clobetasol propionate 0.05% spray on health-related quality of life in patients with plaque psoriasis". review. Journal of Drugs in Dermatology.
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Biogen was founded in 1978 in Geneva as Biotechnology Geneva by several prominent biologists, including Kenneth Murray from the University of Edinburgh, Phillip Allen Sharp from the Massachusetts Institute of Technology, Walter Gilbert from Harvard University (Gilbert served as CEO during the start-up phase of Biogen), Heinz Schaller from the University of Heidelberg, and Charles Weissmann ...
And while you’re likely familiar with the not-so-nice ways that UV exposure can assault skin (damaging collagen, causing skin discoloration, and contributing to skin cancer), dermatologists also ...
Psoriasis has been estimated to affect about 6.7 million Americans. [5] Psoriasis can occur at any age, although it is more frequent in adults and commonly appears for the first time between the ages of 15 and 25 years. [5] Approximately one-third of people with psoriasis report being diagnosed before age 20. [132] Psoriasis affects both sexes ...
Tazarotene is most commonly used topically to treat acne vulgaris and psoriasis. [4] Like other topical retinoids, such as tretinoin and adapalene, tazarotene can be combined with benzoyl peroxide or an oral antibiotic, such as clindamycin or dapsone, for the treatment of acne. [8] This results in increased efficacy compared to tazarotene ...
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