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Histology of a normal lymphoid follicle, with marginal zone annotated at bottom. It is composed of cells derived primarily from the myeloid compartment of bone marrow differentiation. More recently, a population of neutrophil-killers has been described to populate peripheral areas of the marginal zone. [ 4 ]
The spleen is the largest collection of lymphoid tissue in the body. It is normally palpable in preterm infants, in 30% of normal, full-term neonates, and in 5% to 10% of infants and toddlers. A spleen easily palpable below the costal margin in any child over the age of three to four years should be considered abnormal until proven otherwise.
Anatomy Atlases – Microscopic Anatomy, plate 09.175 - "Spleen: Red Pulp" Histology image: 07803loa – Histology Learning System at Boston University - "Lymphoid Tissues and Organs: splenic reticulum"
Histology of a normal lymphoid follicle, with marginal zone annotated at bottom.. Marginal-zone B cells (MZ B cells) are noncirculating mature B cells that in humans segregate anatomically into the marginal zone (MZ) of the spleen [1] and certain other types of lymphoid tissue. [2]
White pulp is a histological designation for regions of the spleen (named because it appears whiter than the surrounding red pulp on cross section), that encompasses approximately 25% of splenic tissue. White pulp consists entirely of lymphoid tissue.
The spleen is made of red pulp and white pulp, separated by the marginal zone; 76–79% of a normal spleen is red pulp. [4] Unlike white pulp, which mainly contains lymphocytes such as T cells, red pulp is made up of several different types of blood cells, including platelets, granulocytes, red blood cells, and plasma. [1]
Germinal centers or germinal centres (GCs) are transiently formed structures within B cell zone (follicles) in secondary lymphoid organs – lymph nodes, ileal Peyer's patches, and the spleen [1] – where mature B cells are activated, proliferate, differentiate, and mutate their antibody genes (through somatic hypermutation aimed at achieving higher affinity) during a normal immune response ...
This category is for articles about the Spleen, an organ found in virtually all vertebrate animals with important roles in regard to red blood cells and the immune system. Subcategories This category has only the following subcategory.