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Formaldehyde (Each 0.5 mL dose may contain residual amounts of formaldehyde of less than 2.66 μg (0.000532%), by calculation), phosphate buffers [8] Meningococcal vaccine Lactose, thimerosal (multi-dose vial only) Meningococcal vaccine Amino acids, formaldehyde, yeast extract MMR vaccine
Thimerosal is used in these multi-dose vials to prevent contamination from multiple preparations. Contamination of the vaccine could cause serious infection. In a .5mL dose (which is in a single flu shot), there is 25 μg (micrograms) of mercury. This is 0.01% of the dose. [40] Single dose vials do not contain thimerosal.
Preservatives prevent the growth of bacteria and fungi, and are more commonly used in vaccines produced as multi-dose vials. They must also be non-toxic in the dose used and not adversely affect the immunogenicity of the vaccine. [29] Thiomersal is the best known and most controversial preservative. It was phased out of UK vaccines between 2003 ...
ACIP statements are official federal recommendations for the use of vaccines and immune globulins in the U.S., and are published by the CDC. ACIP reports directly to the CDC director, although its management and support services are provided by CDC's National Center for Immunization and Respiratory Diseases. [1]
CDC Vaccine Information Statement for MMR Vaccine from April 2012. According to the 1993 amended National Childhood Vaccine Injury Act (NCVIA), a VIS must contain at least the following four components: (1) a description of the benefits of the given vaccine, (2) a description of its risks, (3) information about the National Vaccine Injury Compensation Program (VICP), and (4) other relevant ...
There are different types of vials such as a single dose vial and multi-dose vials often used for medications. The single dose vial is only used once whereas a multi-dose vial can be used more than once. The CDC sets specific guidelines on multi-dose vials.
Two vaccines (a TD and the single-dose version of the trivalent influenza vaccine Fluvirin) that may contain a trace of thiomersal from steps in manufacture, but less than 1 microgram of mercury per dose. [18] The multi-dose versions of some trivalent and quadrivalent influenza vaccines can contain up to 25 micrograms of mercury per dose from ...
[22] [23] They asked vaccine makers to remove thiomersal from vaccines as quickly as possible as a precautionary measure, and it was rapidly phased out of most US and EU vaccines, [24] [25] but is still used in multi-dose vials of flu vaccines in the U.S. [26] [27] No vaccines in the European Union currently contain thiomersal as a preservative ...