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Chemical structure of rapamycin, a pharmaceutical under evaluation for its effects on longevity. The project engages the general public to register their dogs in the studies, and therefore the project is an example of citizen science. [3] As of 2022 nearly 40,000 dogs have been registered with the project. [1]
Kaeberlein's study is part of the dog aging project, which with the help of their owners, is tracking tens of thousands of dogs. The goal: identifying how factors like genes, lifestyle, and ...
Serious side effects including hypersensitivity and swelling have been observed in renal transplant patients. [22] While sirolimus was considered for treatment of LAM, it received orphan drug designation status because LAM is a rare condition. [22] The safety of LAM treatment by sirolimus in people younger than 18 years old has not been tested.
mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration. They function by inhibiting the mammalian target of rapamycin (mTOR) (also known as the mechanistic target of rapamycin), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases ...
1. Ketogenic Diet. Cancer cells rely on glucose for energy to grow. The ketogenic diet is a way to provide an alternative energy source to normal cells in the dog's body while starving the cancer ...
By 2006, an extensive body of work from several independent studies, including studies from yeast to mammals, all pointed to rapamycin as having an anti-aging effect or at least slowing down the ...
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