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Trazodone is metabolized by several liver enzymes, including CYP3A4, CYP2D6, and CYP1A2. [11] [77] Its active metabolite meta-chlorophenylpiperazine (mCPP) is known to be formed by CYP3A4 and metabolized by CYP2D6. [11]
mCPP is metabolized via the CYP2D6 isoenzyme by hydroxylation to ... mCPP is a metabolite of a variety of other piperazine drugs including trazodone, nefazodone ...
CYP3A4 is a member of the cytochrome P450 superfamily of enzymes.The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of steroids (including cholesterol), and other lipids.
Metabolism Dose; Ondansetron: Carbazole derivative 5-HT 3 receptor antagonist and weak 5-HT 4 antagonist 3.9 hours CYP1A1/2, CYP2D6, CYP 3A3/4/5: 150 μg/kg Granisetron: Indazole: 5-HT 3 receptor antagonist 9–11.6 hours CYP3A3/4/5: 10 μg/kg Dolasetron: Indole: 5-HT 3 receptor antagonist 7–9 hours CYP 3A3/4/5, CYP2D6: 600 – 3000 μg/kg ...
Tamoxifen (Nolvadex): Tamoxifen is metabolized by CYP2D6 into its active metabolite 4-hydroxytamoxifen. Grapefruit juice may potentially reduce the effectiveness of tamoxifen. [84] Trazodone (Desyrel): Little or no interaction with grapefruit juice. [85] Verapamil (Calan SR, Covera HS, Isoptin SR, Verelan): atrioventricular conduction disorders ...
Chemical structure of the serotonin antagonist and reuptake inhibitor trazodone. Serotonin antagonist and reuptake inhibitors ( SARIs ) are a class of drugs used mainly as antidepressants , but also as anxiolytics and hypnotics .
Nefazodone is a phenylpiperazine compound and is related to trazodone. ... and may interact adversely with many commonly used medications that are metabolized by ...
Celexa – an antidepressant of the SSRI class; Centrax – an anti-anxiety agent; Clozaril – atypical antipsychotic used to treat resistant schizophrenia; Concerta (methylphenidate) – an extended release form of methylphenidate