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Synthetic cannabinoids reagent testing kits have recently [as of?] become economical. It is often difficult to determine what is in these products without reagent testing because masking agents, such as tocopherol (or vitamin E acetate that causes vaping-associated pulmonary injury), eugenol, and fatty acids, are added to confound identification.
It was often sold in legal smoke blends collectively known as "spice". Several countries and states have moved to ban it legally. JWH-073; CP-55940, produced in 1974, this synthetic cannabinoid receptor agonist is many times more potent than THC. Dimethylheptylpyran; HU-210, about 100 times as potent as THC [101]
JWH-018 is a full agonist of both the CB 1 and CB 2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB 1 and 2.94 ± 2.65 nM at CB 2. [6] JWH-018 has an EC 50 of 102 nM for human CB 1 receptors, and 133 nM for human CB 2 receptors. [16]
Marketed under the names spice, spike, flamingo, or K2 — this underground drug has become one of the most inexpensive and dangerous ways to get high, reports say. Videos surfacing online have ...
Synthetic cannabis: "Spice", "K2", JWH-018, AM-2201 Quaaludes : A popular club drug in the 1970s. No longer prescribed or manufactured in many countries but remains popular in South Africa.
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The classical model of drug cutting refers to the way that illicit drugs were diluted at each stage of the chain of distribution. [1]Drug markets have changed considerably since the 1980s; greater competition, and a shift from highly structured (and thus controlled) to greatly fragmented markets, has generated competition among dealers in terms of purity.
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