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The drugs they studied included cocaine and a few others that have some similarities to cocaine in how they affect the brain. They trained the monkeys to give themselves these drugs through injections and observed their behavior. They wanted to see if the drugs had similar effects on the monkeys.
This suggests a positive neuromodulatory action of CART on the effects of psychostimulants in rats. [18] CART is altered in the ventral tegmental area of cocaine overdose victims, and a mutation in the CART gene is associated with alcoholism. [19] By inhibiting the rewarding effects of cocaine, CART has a potential use in treating cocaine ...
Cocaine is a relatively "balanced" inhibitor, although facilitation of dopaminergic neurotransmission is what has been linked to the reinforcing and addictive effects. In addition, cocaine has some serious limitations in terms of its cardiotoxicity [194] due to its local anesthetic activity. Thousands of cocaine users are admitted to emergency ...
The test can detect antipsychotic-like activity both in the case of dopamine D 2 receptor antagonists and in the case of drugs lacking D 2 receptor antagonism. [1] [2] [6] The occupancy of the D 2 receptor by antagonists of this receptor required to inhibit the CAR is around 65 to 80%, which is similar to the occupancy at which therapeutic antipsychotic effects occur in humans with these drugs.
An EEG is a noninvasive test that measures electrical activity in the brain using small metal discs called electrodes, which are attached to the scalp. These tests provide “quick and accurate ...
JHW-007 is a cocaine analogue and a high affinity atypical dopamine reuptake inhibitor that is being researched for the treatment of cocaine addiction.JHW-007 has been found to blunt the psychostimulant effects of cocaine and reduce self-administration in rodents. [1]
SB-242084 is a selective antagonist of the serotonin 5-HT 2C receptor which is used in scientific research. [1]It has anxiolytic effects-like effects in rodents, [2] and enhances dopamine signalling in the limbic system, [3] as well as having complex effects on the dopamine release produced by cocaine, increasing it in some brain regions [4] [5] but reducing it in others.
"This study demonstrated that specific dog activities could activate stronger relaxation, emotional stability, attention, concentration, and creativity by facilitating increased brain activity ...