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THC, the main psychoactive component of cannabis, may only be detectable in saliva and oral fluid for 2–24 hours in most cases. [8] [9] The main metabolite excreted in the urine is 11-Nor-9-carboxy-THC, also known as THC-COOH. Most cannabis drug tests yield a positive result when the concentration of THC-COOH in urine exceeds 50 ng/mL. [10]
These are achieved at lower doses, because many synthetic cannabinoids are more potent than marijuana, and users are often unaware of exactly what they are getting and how potent it is. [55] For example, Δ 9-THC has an EC 50 of 250 nM at CB 1 and 1157 nM at CB 2, whereas PB-22 has an EC 50 of 5.1 nM at CB 1 and 37 nM at CB 2. [8]
As a result, cannabis edibles as such have caused the most healthcare visits as compared to other forms of cannabis consumption. [1] (Additionally, the amount of THC in any individual product may be highly variable.) [1] Additionally people can have very different responses to the same amount of THC with 2.5 mg being enough for some people to ...
Samples seized across the United States by the Drug Enforcement Administration over an 18-year period (1980–1997) showed that THC content in hashish and hashish oil averaging 12.9% and 17.4%, respectively, did not show an increase over time. [7] The highest THC concentrations measured were 52.9% in hashish and 47.0% in hash oil. [8]
In day-to-day practice, a history of marijuana use is often not sought by many practitioners, and even when sought, the patient's response is not always truthful". [75] A 2013 analysis of 3,886 myocardial infarction survivors over an 18-year period showed "no statistically significant association between marijuana use and mortality". [76]
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Demand is high for pharmaceutical grade THC and other cannabinoids due to interest in their potential therapeutic use, but is stymied by legal regulations of C. sativa cultivation in many countries. [13] Direct chemical synthesis of THC is difficult due to high costs and low yields. [14]
Over time, the marijuana gateway hypothesis has been studied more and more. In one published study, the use of marijuana was shown not a reliable gateway cause of illicit drug use. [67] However, social factors and environment influence drug use and abuse, making the gateway effects of cannabis different for those in differing social circumstances.
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