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Ketamine is a dissociative anesthetic used medically for induction and maintenance of anesthesia. It is also used as a treatment for depression and in pain management. [19] Ketamine is an NMDA receptor antagonist which accounts for most of its psychoactive effects. [20]
And when done under appropriate medical supervision, ketamine is safe. “It is almost impossible to die from an overdose of ketamine alone,” he said, because it doesn’t lower respiration ...
Ketamine's rise in the dance culture was most rapid in Hong Kong by the end of the 1990s. [32] Ketamine use as a recreational drug has been implicated in deaths globally, with more than 90 deaths in England and Wales in the years of 2005–2013. [37] They include accidental poisonings, drownings, traffic accidents, and suicides. [37]
Ketamine, one of the most popular NMDA receptor antagonists. NMDA receptor antagonists are a class of drugs that work to antagonize, or inhibit the action of, the N -Methyl- D -aspartate receptor (NMDAR). They are commonly used as anesthetics for humans and animals; the state of anesthesia they induce is referred to as dissociative anesthesia.
A 2000 landmark study showcased the drug's antidepressant and anti-suicidal effects, and more recent studies have supported ketamine's high rate of success in treating persistent depression.
Ketamine is generally safe when taken under medical supervision, experts said, but the Perry case also underscores potential risks. Ketamine is generally safe when taken under medical supervision ...
Norketamine. Norketamine, or N-desmethylketamine, is the major active metabolite of ketamine, which is formed mainly by CYP3A4. [ 1 ][ 2 ] Similarly to ketamine, norketamine acts as a noncompetitive NMDA receptor antagonist, [ 1 ][ 3 ] but is about 3–5 times less potent as an anesthetic in comparison. [ 2 ][ 4 ]
Almost a year after the death of beloved Friends star Matthew Perry—and nine months after an autopsy concluded he had died from the acute effects of the anesthetic ketamine—several arrests ...