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  2. Insulin signal transduction pathway - Wikipedia

    en.wikipedia.org/wiki/Insulin_signal...

    The insulin transduction pathway is a biochemical pathway by which insulin increases the uptake of glucose into fat and muscle cells and reduces the synthesis of glucose in the liver and hence is involved in maintaining glucose homeostasis. This pathway is also influenced by fed versus fasting states, stress levels, and a variety of other ...

  3. AIDA interactive educational freeware diabetes simulator

    en.wikipedia.org/wiki/AIDA_interactive...

    This is because many of the principles of insulin dosage adjustment are remarkably similar in both type 1 and type 2 diabetes mellitus, and even without an endogenous insulin secretion model function, AIDA still can offer realistic simulations (from an educational perspective) for people with non-insulin dependent (type 2) diabetes mellitus ...

  4. GLUT4 - Wikipedia

    en.wikipedia.org/wiki/GLUT4

    The insulin signal transduction pathway begins when insulin binds to the insulin receptor proteins. Once the transduction pathway is completed, the GLUT-4 storage vesicles becomes one with the cellular membrane. As a result, the GLUT-4 protein channels become embedded into the membrane, allowing glucose to be transported into the cell.

  5. Blood sugar regulation - Wikipedia

    en.wikipedia.org/wiki/Blood_sugar_regulation

    This hormone, insulin, causes the liver to convert more glucose into glycogen (this process is called glycogenesis), and to force about 2/3 of body cells (primarily muscle and fat tissue cells) to take up glucose from the blood through the GLUT4 transporter, thus decreasing blood sugar.

  6. Glucokinase - Wikipedia

    en.wikipedia.org/wiki/Glucokinase

    The amount of glucokinase can be increased by synthesis of new protein. Insulin is the principal signal for increased transcription, operating mainly by way of a transcription factor called sterol regulatory element binding protein-1c (SREBP1c) in the liver. This occurs within an hour after a rise in insulin levels, as after a carbohydrate meal.

  7. File:Signal Transduction Diagram- Insulin.svg - Wikipedia

    en.wikipedia.org/wiki/File:Signal_Transduction...

    You are free: to share – to copy, distribute and transmit the work; to remix – to adapt the work; Under the following conditions: attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made.

  8. Randle cycle - Wikipedia

    en.wikipedia.org/wiki/Randle_cycle

    The Randle cycle, also known as the glucose fatty-acid cycle, is a metabolic process involving the cross inhibition of glucose and fatty acids for substrates. [1] It is theorized to play a role in explaining type 2 diabetes and insulin resistance.

  9. File:Insulin path.svg - Wikipedia

    en.wikipedia.org/wiki/File:Insulin_path.svg

    English: Insulin undergoes extensive posttranslational modification along the production pathway. Production and secretion are largely independent; prepared insulin is stored awaiting secretion. Both C-peptide and mature insulin are biologically active. Cell components and proteins in this image are not to scale.

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