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Members of the Argonaute (Ago) protein family are central to RISC function. Argonautes are needed for miRNA-induced silencing and contain two conserved RNA binding domains: a PAZ domain that can bind the single stranded 3' end of the mature miRNA and a PIWI domain that structurally resembles ribonuclease-H and functions to interact with the 5 ...
Function Distribution Ref. Small nuclear RNA: snRNA: Splicing and other functions: Eukaryotes and archaea [3] Small nucleolar RNA: snoRNA: Nucleotide modification of RNAs: Eukaryotes and archaea [4] SmY RNA: SmY: mRNA trans-splicing: Nematodes [5] Small Cajal body-specific RNA: scaRNA: Type of snoRNA; Nucleotide modification of RNAs: Guide RNA ...
MicroRNAs function to regulate the expression levels of other genes by several mechanisms. mir-221 is an oncogenic microRNA. [1] It targets CD117, which then prevents cell migration and proliferation in endothelial cells. [2] [3] miR-221 is known as an anti angiogenic miRNA.
Recent studies have shown that the Hth and Tsh which are found to be important in cell survival of the Drosophila anterior optimal disc participate in the regulation of the Bantam miRNA. [2] It is concluded that the miRNA has an important function in the central pacemaker of the Drosophila circadian rhythm clock.
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n/a Ensembl ENSG00000284190 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 17: 59.84 – 59.84 Mb n/a PubMed search n/a Wikidata View/Edit Human microRNA 21 also known as hsa-mir-21 or miRNA21 is a mammalian microRNA that is encoded by the MIR21 gene. MIRN21 was one of the first mammalian microRNAs identified. The mature miR-21 sequence is strongly ...
p53-deficient human gastric cancer cells, restoration of functional miR-34 inhibits cell growth and induces chemosensitization and apoptosis, indicating that miR-34 may restore p53 function. Restoration of miR-34 inhibits tumorsphere formation and growth, which is reported to be correlated to the self-renewal of cancer stem cells.
In molecular biology mir-210 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.. mir-210 has been strongly linked with the hypoxia pathway, and is upregulated in response to Hypoxia-inducible factors. [1]