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To identify liquid-liquid phase separation and formation of condensate liquid droplets, one needs to demonstrate the liquid behaviors (viscoelasticity) of the condensates. Furthermore, mechanical processes are key to condensate related diseases, as pathological changes to condensates can lead to their solidification.
Liquid-liquid phase separation (LLPS) is well defined in the Biomolecular condensate page. LLPS databases cover different aspects of LLPS phenomena, ranging from cellular location of the Membraneless Organelles (MLOs) to the role of a particular protein/region forming the condensate state.
It compares pi-pi interactions predicted in the target proteins with all proteins found in the PDB to assign a score of phase-separation propensity. [3] catGRANULE [4] 2016 catGRANULE is a method that was originally trained against yeast protein but it has been shown to be useful to predict human phase-separating proteins. [5]
The most common type of phase separation is between two immiscible liquids, such as oil and water. This type of phase separation is known as liquid-liquid equilibrium. Colloids are formed by phase separation, though not all phase separations forms colloids - for example oil and water can form separated layers under gravity rather than remaining ...
Coacervate droplets dispersed in a dilute phase. Coacervate (/ k oʊ ə ˈ s ɜːr v ə t / or / k oʊ ˈ æ s ər v eɪ t /) is an aqueous phase rich in macromolecules such as synthetic polymers, proteins or nucleic acids. It forms through liquid-liquid phase separation (LLPS), leading to a dense phase in thermodynamic equilibrium with a ...
She builds artificial cells and uses liquid-liquid phase separation and molecular self-assembly. [3] She is interested in the structure-function properties of biomolecular materials. Her research looks to inform the design of pharmaceuticals and bioinspired materials.
Phase inversion is a common method to form filtration membranes, which are typically formed using artificial polymers. The method of phase inversion is highly dependent on the type of polymer used and the solvent used to dissolve the polymer. Phase inversion can be carried out through one of four typical methods: [1]
Membrane distillation (MD) is a thermally driven separation process in which separation is driven by phase change.A hydrophobic membrane presents a barrier for the liquid phase, allowing the vapour phase (e.g. water vapour) to pass through the membrane's pores. [1]