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Spontaneously hypertensive rat (SHR) is a laboratory rat which is an animal model of primary hypertension, used to study cardiovascular disease.It is the most studied model of hypertension measured as number of publications. [1]
This breed of rat was first produced by the Sprague Dawley farms (later to become the Sprague Dawley Animal Company) in Madison, Wisconsin, in 1925. The name was originally hyphenated, although the brand styling today (Sprague Dawley, the trademark used by Inotiv) is not. The average litter size of the Sprague Dawley rat is 11.0. [29]
PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) is one of the most abundant heterocyclic amines (HCAs) in cooked meat. PhIP is formed at high temperatures from the reaction between creatine or creatinine (found in muscle meats), amino acids, and sugar.
Harlan UK Ltd. is the British arm of Harlan Sprague Dawley Inc. It has an annual turnover of £6.6 million, according to the British Union for the Abolition of Vivisection (BUAV). [6] The company supplies marmosets, beagles, cats, rabbits, guinea pigs, rats, mice, gerbils, and hamsters, as well as hybrid, mutant, and transgenic animals.
Laboratory rat#Sprague Dawley rat To a section : This is a redirect from a topic that does not have its own page to a section of a page on the subject. For redirects to embedded anchors on a page, use {{ R to anchor }} instead .
Streptococcus orisratti is a species of oral Streptococcus bacteria first isolated from Sprague–Dawley rats, hence its name. Its type strain is A63 T (=ATCC 700640 ...
BALB/c is an albino, laboratory-bred strain of the house mouse from which a number of common substrains are derived. Now over 200 generations from New York in 1920, BALB/c mice are distributed globally, and are among the most widely used inbred strains used in animal experimentation.
Sprague-Dawley Rats Oral (by gavage) 100, 300, 600, and 900 mg/kg/day Reduced maternal body weight gain from 73 g in controls to 48 and 43 g in the 600 and 900 mg/kg/day dose groups, respectively. [42] Wistar Rats Oral (by gavage) 600 mg/kg bw/day Reductions in fetal plasma leptin levels and in fetal insulin levels. Prenatal exposure disrupts ...