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Common side effects include abdominal pain, nausea, headaches, and muscle pains. [6] Serious side effects may include rhabdomyolysis, liver problems, and diabetes. [6] Use during pregnancy may harm the baby. [6] Like all statins, rosuvastatin works by inhibiting HMG-CoA reductase, an enzyme found in the liver that plays a role in producing ...
The most important adverse side effects are muscle problems, an increased risk of diabetes mellitus, and increased liver enzymes in the blood due to liver damage. [ 5 ] [ 65 ] Over 5 years of treatment statins result in 75 cases of diabetes, 7.5 cases of bleeding stroke , and 5 cases of muscle damage per 10,000 people treated. [ 34 ]
AstraZeneca (AZN) announced Tuesday that its drug, Crestor, had been approved in the European Union to prevent heart attacks and strokes in patients with normal -- and even low -- cholesterol levels.
Several genetic polymorphisms may be linked to an increase in statin-related side effects with single nucleotide polymorphisms (SNPs) in the SLCO1B1 gene showing a 45 fold higher incidence of statin related myopathy [104] than people without the polymorphism. There are several studies showing genetic variants and variable response to atorvastatin.
Earlier this week, AstraZeneca's (AZN) widely used cholesterol-lowering drug Crestor was approved by the U.S. Food and Drug Administration for use in people with normal cholesterol to prevent ...
Pharmaceutical firm Actavis has reached an agreement with big pharma's AstraZeneca to launch a generic version of the latter's cholesterol-fighting drug Crestor in 2016. Actavis agreed to launch ...
Simvastatin is an effective serum lipid-lowering drug that can decrease low density lipoprotein (LDL) levels by up to 50%. [citation needed] Simvastatin had been shown to interact with lipid-lowering transcription factor PPAR-alpha [36] and that interaction might control the neurotrophic action of the drug.
Shares of pharmaceutical giant AstraZeneca are up a modest 8.5% since the start of 2013, but the company is facing a number of headwinds. Generic statins are eating into the sales of its best ...
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