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Female fertility agents are medications that improve female’s ability to conceive pregnancy. These agents are prescribed for infertile female who fails to conceive pregnancy after 1-year of regular and unprotected sexual intercourse. [1] The following will cover the advancements of female fertility agents, major causes of female infertility.
Letrozole, sold under the brand name Femara among others, is an aromatase inhibitor medication that is used in the treatment of breast cancer for post-menopausal women. [ 1 ] It was patented in 1986 and approved for medical use in 1996. [ 4 ]
The Fertility Clinic Success Rate and Certification Act (FCSRCA) of 1992 are United States regulatory requirements that mandate all assisted reproductive technology (ART) clinics report pregnancy success rates data to the Centers for Disease Control and Prevention (CDC) in a standardized manner and for the CDC to publish pregnancy success rates .
Pregnancy rate is the success rate for getting pregnant.It is the percentage of all attempts that leads to pregnancy, with attempts generally referring to menstrual cycles where insemination or any artificial equivalent is used, which may be simple artificial insemination (AI) or AI with additional in vitro fertilization (IVF).
As a result of the 1992 Fertility Clinic Success Rate and Certification Act, the CDC is required to publish the annual ART success rates at U.S. fertility clinics. [29] Assisted reproductive technology procedures performed in the U.S. has over than doubled over the last 10 years, with 140,000 procedures in 2006, [ 30 ] resulting in 55,000 births.
Infertility rates have increased by 4% since the 1980s, mostly from problems with fecundity due to an increase in age. [89] Fertility problems affect one in seven couples in the UK. Most couples (about 84%) who have regular sexual intercourse (that is, every two to three days) and who do not use contraception get pregnant within a year.
A woman whose menstrual cycles ranged in length from 30 to 36 days would be estimated to be infertile for the first 11 days of her cycle (30-19=11), to be fertile on days 12–25, and to resume infertility on day 26 (36-10=26). When used to avoid pregnancy, such fertility awareness-based methods have a typical-use failure rate of 25% per year. [18]
Aromatase inhibitors are a common fertility treatment to treat women with PCOS. A meta-analysis analyzing live birth rates for women with PCOS treated with clomiphene compared to letrozole found that letrozole resulted in higher live birth rates. [11] However, ovulation induction remains an off-label indication, which affects use.