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In mixed tumors, giant cells are more likely to be found in higher proportions at the edge of a tumor. [11] When extensive necrosis is present, it is possible for a giant-cell tumor to have only a thin rim of viable cells remaining at the perimeter of the mass. [citation needed]
Tenosynovial giant cell tumor (TGCT) is a non-malignant tumor defined histologically as inclusions of “osteoclast-like” multinucleated giant cells, hemosiderin, and macrophages. [1] This histology can present one of 2 clinically distinct ways. TGCT tumors often develop from the lining of joints (also known as synovial tissue).
A giant cell (also known as a multinucleated giant cell, or multinucleate giant cell) is a mass formed by the union of several distinct cells (usually histiocytes), often forming a granuloma. [ 1 ] Although there is typically a focus on the pathological aspects of multinucleate giant cells (MGCs), they also play many important physiological roles.
Further proof that these Touton giant cells are histiocytic in origin, meaning they arise from a macrophage-lineage cell, is the fact they react positively to enzymes found in histiocytes such as lysozyme, alpha 1-anti-trypsin and alpha 1-anti-chymotrypsin. Touton giant cells are able to express these proteins which are involved in actions such ...
The giant-cell glioblastoma is a histological variant of glioblastoma, presenting a prevalence of bizarre, multinucleated (more than 20 nuclei) giant (up to 400 μm diameter) cells. It occasionally shows an abundant stromal reticulin network and presents a high frequency of TP53 gene mutations .
As such, the term lives on in the names of many conditions, even when the size of the cell is no longer one of the most important diagnostic criteria. The phrase giant cell is also frequently used, especially with carcinoma. Giant cell tumors include giant-cell tumor of bone, giant-cell tumor of the tendon sheath, [1] and giant cell ...
Malignancy in giant-cell tumor is uncommon and occurs in about 2% of all cases. However, if malignant degeneration does occur, it is likely to metastasize to the lungs. Giant-cell tumors are normally benign, [1] with unpredictable behavior. [2] It is a heterogeneous tumor composed of three different cell populations.
Benign tumors of bone can be similar macroscopically and require a combination of a clinical history with cytogenetic, molecular, and radiologic tests for diagnosis. [23] Three common forms of benign bone tumors with are giant cell tumor of bone, osteochondroma, and enchondroma; other forms of benign bone tumors exist but may be less prevalent.