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The mdx mouse is a popular model for studying Duchenne muscular dystrophy (DMD). [1] [2] The mdx mouse has a point mutation in its DMD gene, changing the amino acid coding for a glutamine to STOP codon. This causes the muscle cells to produce a small, nonfunctional dystrophin protein. [3]
Curiously, in the mdx mouse model of Duchenne muscular dystrophy, the lack of dystrophin is associated with increased calcium levels and skeletal muscle myonecrosis. The intrinsic laryngeal muscles (ILMs) are protected and do not undergo myonecrosis. [ 65 ]
Acura MDX, a sport utility vehicle introduced by Honda; Mdx mouse, a popular model for studying Duchenne muscular dystrophy; Miami-Dade Expressway Authority, an organization that toll expressways; Middlesex, county in England, Chapman code; Middlesex University, which uses the internet domain name mdx.ac.uk; Mountain Dew MDX, an energy drink
View/Edit Mouse In humans, the DMD gene is located on the short (p) arm of the X chromosome between positions 21.2 and 21.1 Dystrophin is a rod-shaped cytoplasmic protein , and a vital part of a protein complex that connects the cytoskeleton of a muscle fiber to the surrounding extracellular matrix through the cell membrane .
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McArdle graduated with a Bachelor's in Biochemistry from the University of Liverpool in 1988 and completed her PhD [2] studying muscle damage using the mdx mouse model of Duchenne muscular dystrophy. [1]
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