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Reperfusion injury, sometimes called ischemia-reperfusion injury (IRI) or reoxygenation injury, is the tissue damage caused when blood supply returns to tissue (re-+ perfusion) after a period of ischemia or lack of oxygen (anoxia or hypoxia).
This reperfusion results in inflammatory injury through three overlapping mechanisms. Some complimentary combination of, first, mitochondrial damage and, second, endothelial activation , causes a release of reactive oxygen species (ROS), which initiates and/or exacerbates a pathophysiological inflammatory response.
[14] [15] The addition of a drug treatment protocol has been reported to allow recovery of dogs after 16 minutes of clinical death at normal body temperature with no lasting brain injury. [16] Cooling treatment alone has permitted recovery after 17 minutes of clinical death at normal temperature, but with brain injury. [17]
Ischemia-reperfusion (IR) tissue injury is the resultant pathology from a combination of factors, including tissue hypoxia, followed by tissue damage associated with re-oxygenation. IR injury contributes to disease and mortality in a variety of pathologies, including myocardial infarction , ischemic stroke , acute kidney injury , trauma ...
[3] [6] [7] Because irreversible injury occurs within 2–4 hours of the infarction, there is a limited window of time available for reperfusion to work. [citation needed] Thrombolytic drugs are contraindicated for the treatment of unstable angina and NSTEMI [3] [8] and for the treatment of individuals with evidence of cardiogenic shock. [9]
Underwater treadmill is used commonly in animal physical therapy. It provides the benefits of land exercises while decreasing the weight placed on the animal's limbs. Underwater treadmill and swimming can be very useful in dogs recovering from surgery, such as anterior cruciate ligament and cranial cruciate ligament repairs and break repairs ...
The concept of reperfusion has become so central to the modern treatment of acute myocardial infarction, that we are said to be in the reperfusion era. [ 53 ] [ 54 ] Patients who present with suspected acute myocardial infarction and ST segment elevation (STEMI) or new bundle branch block on the 12 lead ECG are presumed to have an occlusive ...
Targeted temperature management (TTM), previously known as therapeutic hypothermia or protective hypothermia, is an active treatment that tries to achieve and maintain a specific body temperature in a person for a specific duration of time in an effort to improve health outcomes during recovery after a period of stopped blood flow to the brain. [1]
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