Search results
Results from the WOW.Com Content Network
Bactrim, Bactrimel (manufactured by Roche and distributed in Europe) Bactrom (Venezuela) Bibactin (manufactured by PPM and distributed in Cambodia and some African countries) Biseptol; Sumetrolim; Co-trimoxazole (used as generic UK name) Cotrim; Deprim (AFT Pharmaceuticals) Diseptyl (Israel)
Absorption. Sulfamethoxazole is well-absorbed when administered topically. It is rapidly absorbed when it is orally administered. [1] Distribution. Sulfamethoxazole distributes into most body tissues as well as into sputum, vaginal fluid, and middle ear fluid. [8] [11] It also crosses the placenta. About 70% of the drug is bound to plasma proteins.
In other cases, topical is defined as applied to a localized area of the body or to the surface of a body part regardless of the location of the effect. [4] [5] By this definition, topical administration also includes transdermal application, where the substance is administered onto the skin but is absorbed into the body to attain systemic ...
Drug delivery to the brain is the process of passing therapeutically active molecules across the blood–brain barrier into the brain.This is a complex process that must take into account the complex anatomy of the brain as well as the restrictions imposed by the special junctions of the blood–brain barrier.
The fastest route of absorption is inhalation. [5] Absorption is a primary focus in drug development and medicinal chemistry, since a drug must be absorbed before any medicinal effects can take place. Moreover, the drug's pharmacokinetic profile can be easily and significantly changed by adjusting factors that affect absorption.
Distribution in pharmacology is a branch of pharmacokinetics which describes the reversible transfer of a drug from one location to another within the body. Once a drug enters into systemic circulation by absorption or direct administration, it must be distributed into interstitial and intracellular fluids.
Furthermore, after absorption from the gastrointestinal tract, such drugs must pass to the liver, where they may be extensively altered; this is known as the first pass effect of drug metabolism. Due to the digestive activity of the stomach and intestines, the oral route is unsuitable for certain substances, such as salvinorin A .
Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems. More generally, xenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemistry, such as any drug ...