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They are one of the most widespread motifs found in protein-protein interactions. To aid protein study, several tools have been developed to predict coiled-coils in protein structures. [3] Many coiled coil-type proteins are involved in important biological functions, such as the regulation of gene expression — e.g., transcription factors.
Coiled-Coil Domain Containing protein 82 (CCDC82) is a protein that in humans, is encoded for by the gene of the same name, CCDC82. The CCDC82 gene is expressed in nearly all of human tissues at somewhat low rates. As of today, there are no patents involving CCDC82 and the function remains unknown.
This domain is a characteristic of the entire protein with the exception of the first twenty-three amino acid residues - MNSRQAWRLFLSQGRGDRWVSRP - which are a mitochondrial targeting site and cleaved. The protein has seven predicted alpha helices, a characteristic of coiled-coil proteins.
Another feature is that TMCO6 has an Arginine rich region that is within the coil-coiled region. [10] This indicates that the Arg rich area might be an important structural feature of the coiled-coil region. There are 17 regions for protein binding, 2 transmembrane domains and an addition of a poly-A tail to the mRNA. [10] An SRP1 is also found ...
654818 Ensembl ENSG00000179256 ENSMUSG00000043298 UniProt A2RU48 Q8BQM7 RefSeq (mRNA) NM_001013698 NM_001039558 RefSeq (protein) NP_001013720 NP_001034647 Location (UCSC) Chr 12: 14.8 – 14.81 Mb Chr 6: 136.81 – 136.81 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Single-pass membrane and coiled-coil domain-containing protein 3 is a protein that is encoded in humans by the SMCO3 ...
The protein has 17 predicted alpha helices sites, a characteristic of coiled-coil proteins, and 1 predicted beta-pleated sheet. The following image shows the predicted regions of alpha helices and beta pleated sheets by two programs STRAP [ 9 ] and Quickphyre: [ 10 ] Note: the consensus secondary structures are shown.
Coiled-coil domain containing 74A is a protein that in humans is encoded by the CCDC74A gene. [3] The protein is most highly expressed in the testis and may play a role in developmental pathways. [4] The gene has undergone duplication in the primate lineage within the last 9 million years, and its only true ortholog is found in Pan troglodytes.
Rootletin, also known as ciliary rootlet coiled-coil protein (CROCC) is a protein in humans that is encoded by the CROCC gene. [ 5 ] [ 6 ] [ 7 ] Rootletin is a component of the ciliary rootlet and, together with CEP68 and CEP250 , is required for centrosome cohesion.