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The S1 domain is a protein domain that was originally identified in ribosomal protein S1 but is found in a large number of RNA-associated proteins. The structure of the S1 RNA-binding domain from the Escherichia coli polynucleotide phosphorylase has been determined using NMR methods and consists of a five-stranded antiparallel beta barrel.
20437 Ensembl ENSG00000196470 ENSMUSG00000036840 UniProt Q8IUQ4 P61092 RefSeq (mRNA) NM_001006610 NM_003031 NM_001006611 NM_009172 RefSeq (protein) NP_001006611 NP_003022 NP_033198 Location (UCSC) Chr 16: 48.36 – 48.45 Mb Chr 8: 87.45 – 87.47 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse E3 ubiquitin-protein ligase SIAH1 is an enzyme that in humans is encoded by the SIAH1 gene ...
Protein S (also known as PROS) is a vitamin K-dependent plasma glycoprotein synthesized in the liver. In the circulation, Protein S exists in two forms: a free form and a complex form bound to complement protein C4b-binding protein (C4BP). In humans, protein S is encoded by the PROS1 gene. [5] [6] Protein S plays a role in coagulation.
Ubiquitin-activating enzymes, also known as E1 enzymes, catalyze the first step in the ubiquitination reaction, which (among other things) can target a protein for degradation via a proteasome. This covalent bond of ubiquitin or ubiquitin-like proteins to targeted proteins is a major mechanism for regulating protein function in eukaryotic ...
About a dozen E2 proteins are known to exist in yeast as transfer proteins that transfer ubiquitin from E1 to E3 or substrates, and it has been confirmed that more types exist in higher eukaryotes than yeast. E3 enzyme, also called E3 ligase, is an enzyme that acts in the final step of attaching ubiquitin to a substrate protein.
In this type of annotation more emphasis is given to genetic variation that disrupts the protein function domain, protein-protein interaction and biological pathway. The non-coding region of genome contain many important regulatory elements including promoter , enhancer and insulator, any kind of change in this regulatory region can change the ...
E3 ubiquitin-protein ligase NEDD4, also known as neural precursor cell expressed developmentally down-regulated protein 4 (whence "NEDD4") is an enzyme that is, in humans, encoded by the NEDD4 gene. [5] [6] NEDD4 is an E3 ubiquitin ligase enzyme, that targets proteins for ubiquitination. [7]
Adenovirus DNA replication begins at each end of the viral DNA, using the TP protein (rather than RNA) as a primer, so the viral DNA polymerase replicates every base of the genome. Membrane protein E3 RID-alpha and membrane protein E3 RID-beta performs a variety of molecular functions that contribute to inhibiting apoptosis. [8]