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Ciclosporin, also spelled cyclosporine and cyclosporin, is a calcineurin inhibitor, used as an immunosuppressant medication. It is taken orally or intravenously for rheumatoid arthritis , psoriasis , Crohn's disease , nephrotic syndrome , eczema , and in organ transplants to prevent rejection .
This is not to be confused with dose regimen, which is a type of drug therapy in which the dose [mg] of a drug is given at a regular dosing interval on a repetitive basis. Continuing the maintenance dose for about 4 to 5 half-lives (t 1/2 ) of the drug will approximate the steady state level. [ 1 ]
The immunosuppressant cyclosporine (ciclosporin) may be recommended to increase tear production and, for short term use, topical corticosteroid medications are also sometimes helpful to reduce inflammation. [6] Another treatment that is sometimes suggested is lacrimal plugs that prevent tears from draining from the surface of the eye.
Upon the original patent expiration, Hi-Tech Pharma was the first of many generic competitors to submit an abbreviated new drug application (ANDA) for dorzolamide hydrochloride/timolol maleate eye drops. [19] Hi-Tech Pharma's ANDA was approved on 28 October 2008. At the time, controversy surrounded the approval of this first ANDA.
The collective effective dose, dose quantity S, is calculated as the sum of all individual effective doses over the time period or during the operation being considered due to ionizing radiation. [ 1 ] : paragraph 159 It can be used to estimate the total health effects of a process or accidental release involving ionizing radiation to an ...
Effective dose is a dose quantity in the International Commission on Radiological Protection (ICRP) system of radiological protection. [1]It is the tissue-weighted sum of the equivalent doses in all specified tissues and organs of the human body and represents the stochastic health risk to the whole body, which is the probability of cancer induction and genetic effects, of low levels of ...
In toxicology, the median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 is a toxic unit that measures the lethal dose of a given substance. [1] The value of LD 50 for a substance is the dose required to kill half the members of a tested population after a specified test duration.
The molecular formula of cetylpyridinium chloride is C 21 H 38 NCl. In its pure form it is a solid at room temperature. It has a melting point of 77 °C when anhydrous or 80–83 °C as a monohydrate. It is soluble in water but insoluble in acetone, acetic acid, or ethanol. It has a pyridine-like odor. It is combustible.
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