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Side effects of melatonin may include sleep disturbance, nightmares, daytime sleepiness, and depression, though the current tendency to use lower doses has decreased such complaints. Large doses of melatonin can even be counterproductive: Lewy et al. [ 48 ] provide support to "the idea that too much melatonin may spill over onto the wrong zone ...
Deficient sleep patterns are prominent in many psychiatric ailments. [18] Insomnia increases the risk of a depressive episode, sleep deprivation influences the onset of hypomania, and sleep disturbance contributes to the maintenance of mood disorders. [19] Amongst manic bipolar patients, sleep loss may act as a trigger in the onset of a manic ...
Sleep problems are particularly common in patients with anxiety, depression, bipolar disorder, and attention deficit hyperactivity disorder (ADHD). [131] The specific causal relationships between sleep loss and effects on psychiatric disorders have been most extensively studied in patients with mood disorders.
Since the REM stages typically occur during the second half of sleep, sleeping too little may not allow the body enough time to complete all the REM sleep cycles, per the National Sleep Foundation.
Not getting enough sleep can also contribute to weight gain. It messes with the body's hormones that control hunger and fullness. When you're tired, you're more likely to feel hungry and less likely to burn calories through exercise. [26] Stress and lack of sleep often go together and can make it much easier to gain weight.
Additionally, lack of sleep causes increased anxiety-like behaviors and impairs the brain's ability to block out unimportant stimuli when performing tasks requiring attention. Disruptions in important brain circuits and the downregulation of proteins necessary for cognitive stability are the causes of these behavioral abnormalities. [ 30 ]
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