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The two important properties of enzyme kinetics are how easily the enzyme can be saturated with a substrate, and the maximum rate it can achieve. Knowing these properties suggests what an enzyme might do in the cell and can show how the enzyme will respond to changes in these conditions.
Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life. The study of how fast an enzyme can transform a substrate into a product is called enzyme kinetics. The rate of reaction of many chemical reactions shows a linear response as function of the concentration of substrate molecules.
A decade before Michaelis and Menten, Victor Henri found that enzyme reactions could be explained by assuming a binding interaction between the enzyme and the substrate. [11] His work was taken up by Michaelis and Menten, who investigated the kinetics of invertase, an enzyme that catalyzes the hydrolysis of sucrose into glucose and fructose. [12]
The molecules progress through the pathway sequentially from the starting substrate to the final product. Each step in the pathway is usually facilitated by a different specific enzyme that catalyzes the chemical transformation. An example includes DNA replication, which connects the starting substrate and the end product in a straightforward ...
Pages in category "Enzyme kinetics" The following 39 pages are in this category, out of 39 total. This list may not reflect recent changes. ...
A comparison of specificity constants can also be used as a measure of the preference of an enzyme for different substrates (i.e., substrate specificity). The higher the specificity constant, the more the enzyme "prefers" that substrate. [1] The following equation, known as the Michaelis–Menten model, is used to describe the kinetics of enzymes:
The enzyme involved in this reaction is called invertase, and it is the enzyme the kinetics of which have been supported by Michaelis and Menten to be revolutionary for the kinetics of other enzymes. While expressing the rate of the reaction studied, they derived an equation that described the rate in a way which suggested that it is mostly ...
Chemical kinetics, the study of chemical reaction rates Enzyme kinetics, the study of biochemical reaction rates catalysed by an enzyme Michaelis–Menten kinetics, the widely accepted general model of enzyme kinetics; Goldbeter–Koshland kinetics, describe a steady-state solution for a 2-state biological system; Langmuir–Hinshelwood kinetics