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Although it is possible for men to father children into old age, the genetic quality of sperm, as well as its volume and motility, all typically decrease with age. [2] Advancing paternal age has been implicated in several possible health effects. One particularly well-studied connection is the link between advancing age and autism. For example ...
Isoflavones occur in many plant species, but are especially high in soybeans. [1] Although isoflavones and closely-related phytoestrogens are sold as dietary supplements, there is little scientific evidence for either the safety of long-term supplementation or of health benefits from these compounds. [1]
Reproductive toxicants may adversely affect sexual function, ovarian failure, fertility as well as causing developmental toxicity in the offspring. [2] [3] Lowered effective fertility related to reproductive toxicity relates to both male and female effects alike and is reflected in decreased sperm counts, semen quality and ovarian failure.
It is unclear if phytoestrogens have any effect on male physiology, with conflicting results about the potential effects of isoflavones originating from soy. [1] Some studies showed that isoflavone supplementation had a positive effect on sperm concentration, count, or motility, and increased ejaculate volume.
Isoflavonoids and their derivatives are sometimes referred to as phytoestrogens, as many isoflavonoid compounds have biological effects via the estrogen receptor. Medically, isoflavonoids and related compounds have been used in many dietary supplements but the medical and scientific community [who?] is generally skeptical of their use.
Sperm motility increases from puberty through one's mid-thirties. Research shows that from the age of 36 onwards, sperm motility decreases from 40% Grade A & B to 31% in one's 50s. The effects of aging on semen quality is summarized below based on a study of 1,219 subjects: [7]
Sperm motility is dependent on several metabolic pathways and regulatory mechanisms. The axonemal bend movement is based on the active sliding of axonemal doublet microtubules by the molecular motor dynein, which is divided into an outer and an inner arm. Outer and inner arm plays different roles in the production and regulation of flagellar motility: the outer arm increase the bea
Lifestyle factors, such as substance use or adiposity, can play a detrimental role in the quality of the semen. One study examining the consequences of alcohol consumption and its effect on semen quality concluded that alcohol intake can lead to a negative effect on semen volume in daily alcohol consumers.