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The blastocyst has a diameter of about 0.1–0.2 mm and comprises 100-200 cells following 7-8 rounds of cleavage (cell division without cell growth). About seven days after fertilization, [ 6 ] the blastocyst undergoes implantation , embedding into the endometrium of the uterine wall where it will undergo further developmental processes ...
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In the mammalian blastocyst there are three lineages that give rise to later tissue development. The epiblast gives rise to the fetus itself while the trophoblast develops into part of the placenta and the primitive endoderm becomes the yolk sac. [6] In the mouse embryo, blastocoel formation begins at the 32-cell stage.
Cavitation is the formation of the blastocoel, a fluid-filled cavity that defines the blastula, or in mammals the blastocyst. [1] After fertilization , cell division of the zygote occurs which results in the formation of a solid ball of cells ( blastomeres ) called the morula .
Image showing the bilaminar embryonic disc with its surrounding structures by day eight of embryonic development. Beginning on day eight, the amniotic sac is the first new cavity to form during the second week of development. [4] Fluid collects between the epiblast and the hypoblast, which splits the epiblast into two portions.
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The morula is now watertight, to contain the fluid that the cells will later pump into the embryo to transform it into the blastocyst. In humans, the morula enters the uterus after three or four days, and begins to take in fluid, as sodium-potassium pumps on the trophoblasts pump sodium into the morula, drawing in water by osmosis from the ...
Embryo culture until the blastocyst stage confers a significant increase in live birth rate per embryo transfer, and there is no evidence of a difference between the groups in cumulative pregnancy rates. [2] Transfer day 2 instead of day 3 after fertilization has no differences in live birth rate. [3]