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An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture, integrated circuit (chip) that simulates the activities, mechanics and physiological response of an entire organ or an organ system. [1] [2] It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS.
Schematic of the Emulate liver-chip [4] Emulate's Organs-on-Chips technology has been used to recreate the function of a variety of different organs, including the liver, intestine, brain, kidney, and lung. [5] The company's Organ-Chips are about the size of a AA battery and feature two fluidic channels that create the flow of blood and other ...
Schematic drawing of a lung-on-a-chip. The membrane in the middle can be stretched by vacuum in the two side chambers. Lung-on-a-chip (LoC), also known as Lung Chips, are micro- and millifluidic organ-on-a-chip devices designed to replicate the structure and function of the human lung, mimicking the breathing motions and fluid dynamics that occur during inhalation and exhalation. [1]
OCs are used in various subcultures including the Star Wars fandom, the Harry Potter fandom, [1] and other subcultures such as the Sonic the Hedgehog fandom. Takashi Iizuka mentioned that the character customization system in Sonic Forces was influenced by the Sonic community's tendency to create original characters; [8] tools for creating Sonic OCs exist on sites like Newgrounds. [9]
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The online video game platform and game creation system Roblox has numerous games (officially referred to as "experiences") [1] [2] created by users of its creation tool, Roblox Studio. Due to Roblox ' s popularity, various games created on the site have grown in popularity, with some games having millions of monthly active players and 5,000 ...
A prominent example of an intestine-on-a-chip system relying on architectural cues is the homeostatic mini-intestines by Nikolaev et al. [24] They use microfabricated intestine-on-a-chip devices with a hydrogel chamber. The collagen-Matrigel-mix hydrogel is laser-ablated to generate a microchannel for a tubular intestinal lumen with crypt ...
The Organ Trail ' s popularity led its developers to start a Kickstarter to fund a "director's cut" of the game based on fan feedback and suggestions. [11] [12] [13] The Director's Cut features a number of changes to the original game, including a customizable protagonist instead of the above preset characters, "choose-your-own-adventure" style random encounters, boss fights, in-game ...