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The TCAs are used primarily in the clinical treatment of mood disorders such as major depressive disorder (MDD), dysthymia, and treatment-resistant variants. They are also used in the treatment of a number of other medical disorders, including cyclic vomiting syndrome (CVS) and anxiety disorders such as generalized anxiety disorder (GAD), social phobia (SP) also known as social anxiety ...
[45] [46] Other secondary amine tricyclic antidepressants include desipramine and protriptyline. [ 47 ] [ 48 ] The chemical name of nortriptyline is 3-(10,11-dihydro-5 H -dibenzo[ a , d ]cyclohepten-5-ylidene)- N -methyl-1-propanamine and its free base form has a chemical formula of C 19 H 21 N 1 with a molecular weight of 263.384 g/mol. [ 49 ...
Duloxetine, tricyclic antidepressants, and anticonvulsants have similar tolerability while opioids cause more side effects. [35] Another review in Prescrire International considered the moderate pain relief achieved with duloxetine to be clinically insignificant and the results of the clinical trials unconvincing.
Maprotiline, sold under the brand name Ludiomil among others, is a tetracyclic antidepressant (TeCA) that is used in the treatment of depression. [5] It may alternatively be classified as a tricyclic antidepressant (TCA), specifically a secondary amine. [5]
All adults under 65 should be screened regularly for anxiety and depression even if they don't have symptoms, health panel urges. Screen all adults under 65 for anxiety, health panel says Skip to ...
Desipramine, sold under the brand name Norpramin among others, is a tricyclic antidepressant (TCA) used in the treatment of depression. [8] It acts as a relatively selective norepinephrine reuptake inhibitor, though it does also have other activities such as weak serotonin reuptake inhibitory, α 1-blocking, antihistamine, and anticholinergic effects.
It is this and its NET-inhibiting action is believed to give amitriptyline its antidepressant action. NET: 22.4: 4.37? See above. DAT: 5380: 3100? 5-HT 1A: 450: 294: 421: Binding for human brain receptors had to be substituted in amitriptyline (AMI) and nortriptyline's (NOR) cases 5-HT 2A: 4.3: 5: 5.6: Binding for cloned rat receptors had to be ...
Amitriptyline, sold under the brand name Elavil among others, is a tricyclic antidepressant primarily used to treat major depressive disorder, and a variety of pain syndromes such as neuropathic pain, fibromyalgia, migraine and tension headaches. [12]