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In toxicology, the median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 is a toxic unit that measures the lethal dose of a given substance. [1] The value of LD 50 for a substance is the dose required to kill half the members of a tested population after a specified test duration.
The probable lethal oral dose in humans is 1.5 to 2 mg/kg. [2] Similarly, the median lethal dose for dogs, cats, and rats ranges from 0.5 to 2.35 mg/kg. [3]
The median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 (lethal concentration and time) of a toxin, radiation, or pathogen is the dose required to kill half the members of a tested population after a specified test duration.
Absolute lethal concentration, LC 100; Absolute lethal dose, LD 100 The most referenced value in the chemical industry is the median lethal dose, or LD50. This is the concentration of substance which resulted in the death of 50% of test subjects (typically mice or rats) in the laboratory.
LT50 is the median Lethal Time (time until death) [1] [2] after exposure of an organism to a toxic substance or stressful condition. LT50 is commonly used in toxicology studies to quantify amount of a stressor necessary to kill an organism. LT50 can be used in conjunction with EC50 (median Exposure Concentration) for even more precise ...
Food products and household items commonly handled by humans can be toxic to dogs. The symptoms can range from simple irritation to digestion issues, behavioral changes, and even death. The categories of common items ingested by dogs include food products, human medication, household detergents, indoor and outdoor toxic plants, and rat poison. [1]
Most health claims on fish oil supplements are unfounded A 2023 study analyzed the labels of more than 2,800 fish oil supplements and found that 2,082 — nearly 74% — made at least one health ...
The LD 50 ("Lethal Dose 50%") test is used to evaluate the toxicity of a substance by determining the dose required to kill 50% of the test animal population. This test was removed from OECD international guidelines in 2002, replaced by methods such as the fixed dose procedure, which use fewer animals and cause less suffering.
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