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Discoid lupus erythematosus (DLE) is an uncommon autoimmune disease of the basal cell layer of the skin. It occurs in humans [1] and cats, more frequently occurring in dogs. It was first described in dogs by Griffin and colleagues in 1979. [2] [3] DLE is one form of cutaneous lupus erythematosus (CLE). DLE occurs in dogs in two forms: a ...
Of the drugs that cause DIL, hydralazine has been found to cause a higher incidence. Hydralazine is a medication used to treat high blood pressure. Approximately 5% of the patients who have taken hydralazine over long periods of time and in high doses have shown DIL-like symptoms. [8] Many of the other drugs have a low to very low risk to ...
In dogs, autoimmune skin diseases are usually not detected until visible symptoms appear, which differs from detection in humans who are able to verbally express their concerns. [2] Genetics , nutrition, and external environmental factors all collectively contribute to increasing the probability an autoimmune skin disease occurring. [ 3 ]
The oral drug, brepocitinib, did not meet the primary study goal of reduction in disease activity at week 52 in patients of SLE, in which the immune system that normally helps protect the body ...
Some drugs approved for other diseases are used for SLE 'off-label'. In November 2010, an FDA advisory panel recommended approving belimumab (Benlysta) as a treatment for the pain and flare-ups common in lupus. The drug was approved by the FDA in March 2011. [121] [122]
diazepam – benzodiazepine used to treat status epilepticus, also used as a preanaesthetic and a sedative; dichlorophene – fungicide, germicide, and antimicrobial agent, also used for the removal of parasites; diphenhydramine – histamine blocker; doxycycline – antibiotic, also used to treat Lyme disease
Treatment options include medications such as NSAIDs, corticosteroids, and joint fluid modifiers such as glycosaminoglycans. Other treatments include surgery, massage, warm compresses, chiropractic, and acupuncture. [35] Hip dysplasia is an inherited disease in dogs that is characterized by abnormal development of the acetabulum and head of the ...
Other oral medications used to treat discoid lupus include retinoids (isotretinoin or acitretin), dapsone, thalidomide (teratogenic, side effects include peripheral neuropathy), azathioprine, methotrexate, or gold. [2] [5] The topical steroid fluocinonide is more effective than hydrocortisone in the treatment of discoid lupus erythematosus. [8]
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