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Azole antifungals are a group of medicines that contain an azole ring and inhibit the growth of a wide range of fungi. They are classified into two groups: those with two nitrogens in the azole ring (the imidazoles; examples include clotrimazole, econazole, ketoconazole, miconazole, and tioconazole) and those with three nitrogens in the azole ...
An azole antifungal with broad-spectrum activity used to treat fungal infections affecting the vagina, mouth and skin, including candidiasis. Econazole A topical antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor.
Azole antifungal agents have added greatly to the therapeutic options for treatment of systemic fungal infections. The azoles that are available for systemic use can be classified into two groups: the triazoles (fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole) and the imidazoles (ketoconazole).
For over two decades, the azole antifungals have been used in clinical practice to treat various fungal infections (TABLE 1). They are categorized into two distinctive classes: the imidazoles and the triazoles.
Azole antifungals that are generally indicated for therapeutic drug concentration monitoring (TDM) all come from the triazole sub-class: itraconazole, voriconazole, posaconazole.
Or they may guide you to an effective over-the-counter (OTC) treatment. Options include: Azoles (fluconazole or Diflucan®), synthetic (human-made) antifungals that keep fungi from growing. Echinocandins (micafungin or Mycamine®), newer semi-synthetic antifungals that attack and damage the fungus wall.
Azole antifungals are used to treat thrush, yeast infection, candidiasis, tinea versicolor, athlete's foot, jock itch, ringworm, nail fungus, fungal infections, and seborrheic dermatitis. They work by slowing down and preventing the growth of fungus.
The azole antifungal agents in clinical use contain either two or three nitrogens in the azole ring and are thereby classified as imidazoles (e.g., ketoconazole and miconazole, clotrimazole) or triazoles (e.g., itraconazole and fluconazole), respectively.
The azole family of antifungal agents has indications for many fungal pathogens. They have relatively few adverse effects compared with older agents such as amphotericin B. Due to improved efficacy and safety, the triazole family has largely replaced early azoles, such as ketoconazole.
Topical antifungals are products that treat fungal infections and which are applied directly to the skin, nails, or hair; vaginally; or inside the mouth. They are available as creams, gels, lotions, nail lacquers, ointments, powders, shampoos, sprays, and tinctures.