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As well as DNA-binding functions, evidence suggests that the ETS domain is also involved in protein-protein interactions. There is limited similarity outside the ETS DNA binding domain. Other domains are also present and vary from ETS member to ETS member, including the Pointed domain, a subclass of the SAM domain family.
ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene. [ 5 ] [ 6 ] The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily.
Protein C-ets-1 is a protein that in humans is encoded by the ETS1 gene. [5] The protein encoded by this gene belongs to the ETS family of transcription factors . [ 6 ]
The protein encoded by this gene is a member of an epithelium-specific subclass of the ETS transcription factor family.In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate.
ETS Like-1 protein Elk-1 is a protein that in humans is encoded by the ELK1. [5] Elk-1 functions as a transcription activator.It is classified as a ternary complex factor (TCF), a subclass of the ETS family, which is characterized by a common protein domain that regulates DNA binding to target sequences.
Tools. Tools. move to ... ETS domain-containing protein Elk-4 is a protein that ... This gene is a member of the Ets family of transcription factors and of the ...
SAM pointed domain-containing Ets transcription factor is a protein that in humans is encoded by the SPDEF gene. [5] [6] [7] PDEF is an ETS transcription factor expressed in prostate epithelial cells. It acts as an androgen-independent transactivator of PSA (MIM 176820) expression.[supplied by OMIM] [7]
ERG (ETS-related gene) is an oncogene. [ 5 ] [ 6 ] [ 7 ] ERG is a member of the ETS (erythroblast transformation-specific) family of transcription factors. [ 8 ] The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator.
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