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Infant botulism (also referred to as floppy baby syndrome) was first recognized in 1976, and is the most common form of botulism in the United States. Infants are susceptible to infant botulism in the first year of life, with more than 90% of cases occurring in infants younger than six months. [ 4 ]
Hypotonia is a state of low muscle tone [1] (the amount of tension or resistance to stretch in a muscle), often involving reduced muscle strength. Hypotonia is not a specific medical disorder, but a potential manifestation of many different diseases and disorders that affect motor nerve control by the brain or muscle strength.
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There is an ultra-rare, fatal infantile-onset phenotype that results in profound muscle weakness ("floppy baby") and respiratory failure within weeks of birth (perinatal asphyxia). Post-mortem biopsy showed a deficiency of myophosphorylase and abnormal glycogen accumulation in skeletal muscle tissue.
It is also used in the expression syndrome du bébé "poupée de son", "floppy baby syndrome" (infantile hypotonia), and can even refer to someone too drunk to stand up. So in the first place, poupée de son refers to a floppy type of doll like a rag doll, with no backbone of its own but which, like a puppet, is under the control of others.
Bahasa Melayu; မြန်မာဘာသာ ... Floppy eyelid syndrome; Florid cutaneous papillomatosis; ... Gray baby syndrome; Greater trochanteric pain syndrome ...
Research has found that there is a correlation between advanced paternal age and risk of birth defects such as limb anomalies, syndromes involving multiple systems, and Down syndrome. [74] [35] [93] Recent studies have concluded that 5-9% of Down syndrome cases are due to paternal effects, but these findings are controversial. [74] [75] [35] [94]
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