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In May 2010, the U.S. Food and Drug Administration (FDA) approved a revised label for Xenical to include new safety information about rare cases of severe liver injury that have been reported with the use of this medication. [33] A 2010 phase 2 trial found cetilistat significantly reduced weight and was better tolerated than orlistat. [34]
Due to high costs, some health plans in the US do not cover weight-loss drugs like semaglutide and tirzepatide. [74] [75] [76] In the United States, as of 2024, about half of private employer-sponsored plans cover these drugs, [77] Federal Medicare Part D does not, and only a few federally-funded, state-administered Medicaid plans do so. [78]
Orlistat is used for the treatment of obesity.The amount of weight loss achieved with orlistat varies. In one-year clinical trials, between 35.5% and 54.8% of subjects achieved a 5% or greater decrease in body mass, although not all of this mass was necessarily fat.
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The NHS is unable to stockpile many of the scarcer drugs because they go out of date, and experts say post-Brexit red tape is making it harder to get life-saving drugs into the UK when they are ...
The British National Formulary (BNF) is a United Kingdom (UK) pharmaceutical reference book that contains a wide spectrum of information and advice on prescribing and pharmacology, along with specific facts and details about many medicines available on the UK National Health Service (NHS).
As a result, different GLP-1 agonist drugs are modified in various ways to extend the half-life, resulting in drugs that can be dosed multiple times per day, daily, weekly, or less often. [29] Most synthetic GLP-1 agonists are delivered via subcutaneous injection , which is a barrier to their use and reason for discontinuation. [ 37 ]
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