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Chlorpromazine is used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of bipolar disorder, as well as amphetamine-induced psychosis. Controversially, some psychiatric patients may be given Chlorpromazine by force, even if they do not suffer any of the typical conditions the drug is prescribed for.
Another method is "defined daily dose" (DDD), which is the assumed average dose of an antipsychotic that an adult would receive during long-term treatment. [15] DDD is primarily used for comparing the utilization of antipsychotics (e.g. in an insurance claim database), rather than comparing therapeutic effects between antipsychotics. [15]
The British National Formulary recommends a gradual dose reduction when discontinuing antipsychotic treatment to avoid acute withdrawal symptoms or rapid relapse. [162] The process of cross-titration involves gradually increasing the dose of the new medication while gradually decreasing the dose of the old medication.
The management of schizophrenia usually involves many aspects including psychological, pharmacological, social, educational, and employment-related interventions directed to recovery, and reducing the impact of schizophrenia on quality of life, social functioning, and longevity.
The results were essentially the same in relief and discharge ratings but chlorpromazine was safer with fewer side-effects, easier to administer, and better suited to long-term care. [citation needed] In 1958, Bourne published a paper on increasing disillusionment in the psychiatric literature about insulin coma therapy for schizophrenia.
The first major tranquilizer or antipsychotic medication, chlorpromazine (Thorazine), a typical antipsychotic, was discovered in 1951 and introduced into clinical practice shortly thereafter. Clozapine (Clozaril), an atypical antipsychotic, fell out of favor due to concerns over drug-induced agranulocytosis .
Due to longstanding pushback and controversial health studies surrounding the ingredient, many processed food manufacturers have already shifted away from using Red Dye No. 3, opting instead for ...
Prochlorperazine is analogous to chlorpromazine; both of these agents antagonize dopaminergic D 2 receptors in various pathways of the central nervous system. This D 2 blockade results in antipsychotic, antiemetic and other effects.
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