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Isotretinoin, also known as Accutane or Roaccutane, is a retinoid that treats severe cystic acne and some skin conditions. It has many side effects, including birth defects, liver problems, and psychiatric issues, and requires strict controls and monitoring.
Stunted growth, also known as stunting or linear growth failure, is impaired growth and development manifested by low height-for-age. It is a primary manifestation of malnutrition and recurrent infections in early childhood and even before birth, and has severe consequences for health, education and productivity.
Retinoic acid (all-trans-retinoic acid) is a signaling molecule that regulates embryonic development, male fertility, bone growth and immune function. It is derived from vitamin A (retinol) and acts through retinoic acid receptors and retinoid X receptors.
iPLEDGE is a program by the U.S. Food and Drug Administration to prevent birth defects caused by isotretinoin, a prescription medication for acne. It requires patients, doctors and pharmacists to register and use the iPLEDGE web site, and imposes strict conditions and tests for patients who can get pregnant.
Bremner's research used PET brain imaging to show a decrease in frontal lobe brain function in acne patients treated with Accutane (isotretinoin). He was an expert witness in litigation related to the relationship between Accutane and suicide and depression, including the case of Charles J. Bishop , [ 3 ] which he describes in the narrative non ...
Learn about the controversies surrounding the use of human growth hormone (HGH) as an anti-aging therapy, based on scientific evidence and legal issues. Find out the potential benefits, side-effects, and dangers of HGH supplementation, as well as the laws and regulations in the US.
Dubowitz syndrome is a rare genetic disorder with microcephaly, stunted growth, and distinctive facial features. It is inherited in an autosomal recessive manner and may be related to cholesterol metabolism defects.
Growth arrest lines are lines of increased bone density that indicate growth arrest in long bones due to malnutrition, disease or trauma. They are visible by radiograph and can be used to estimate the age of the lines formation.