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The Xpert MTB/RIF is a cartridge-based nucleic acid amplification test (NAAT) for rapid tuberculosis diagnosis and rapid antibiotic sensitivity test.It is an automated diagnostic test that can identify Mycobacterium tuberculosis (MTB) DNA and resistance to rifampicin (RIF).
Nucleic acid amplification tests (NAAT) for TB are a heterogeneous group of tests that use either the polymerase chain reaction (PCR) technique or transcription-mediated amplification (TMA) or other forms of nucleic acid amplification methods to detect mycobacterial nucleic acid. These tests vary in which nucleic acid sequence they detect and ...
Rotavirus. A nucleic acid test (NAT) is a technique used to detect a particular nucleic acid sequence and thus usually to detect and identify a particular species or subspecies of organism, often a virus or bacterium that acts as a pathogen in blood, tissue, urine, etc. NATs differ from other tests in that they detect genetic materials (RNA or DNA) rather than antigens or antibodies.
Nucleic acid amplification tests and adenosine deaminase testing may allow rapid diagnosis of TB. [100] Blood tests to detect antibodies are not specific or sensitive , so they are not recommended. [ 107 ]
This is a group of tests that use polymerase chain reaction (PCR) to detect mycobacterial nucleic acid. [14] These test vary in which nucleic acid sequence they detect and vary in their accuracy. The two most common commercially available tests are the amplified mycobacterium tuberculosis direct test (MTD, Gen-Probe) and Amplicor. [15]
Cartridge Based Nucleic Acid Amplification Test (CBNAAT) using the GeneXpert Platform, and TruNat are rapid molecular tests for TB diagnosis and Rifampicin resistance detection . This test is the first choice of diagnostic test for high risk population, children, contacts of drug resistant
A positive acid-fast bacteria (AFB) stain can support the diagnosis. [1] Other possible methods include nucleic acid amplification tests, fine needle aspiration (FNA), or excisional biopsy, the most invasive method. [1] Supplementary studies to aid in diagnosis include tuberculin skin tests, interferon-gamma release assays, or chest X-rays. [1]
A 2010 review study by Puren et al. [2] categorizes viral load testing into three types: (1) nucleic acid amplification based tests (NATs or NAATs) commercially available in the United States with Food and Drug Administration (FDA) approval, or on the market in the European Economic Area (EEA) with the CE marking; (2) "Home–brew" or in-house NATs; (3) non-nucleic acid-based test.
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