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The atypical antipsychotics ( AAP ), also known as second generation antipsychotics ( SGAs) and serotonin –dopamine antagonists ( SDAs ), [ 1][ 2] are a group of antipsychotic drugs (antipsychotic drugs in general are also known as tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) largely ...
Typical antipsychotics have been around longer and are known as first-generation antipsychotics. Atypical antipsychotics are a newer class, known as second-generation antipsychotics. While typical ...
Typical antipsychotic. Typical antipsychotics (also known as major tranquilizers, and first generation antipsychotics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia ). Typical antipsychotics may also be used for the treatment of acute mania, agitation, and other conditions.
The difference between first- and second-generation antipsychotics is a subject of debate. The second-generation antipsychotics are generally distinguishable by the presence of 5HT2A receptor antagonism and a corresponding lower propensity for extrapyramidal side effects compared to first-generation antipsychotics. [15]
Specialty. Neurology. Extrapyramidal symptoms ( EPS) are symptoms that are archetypically associated with the extrapyramidal system of the brain's cerebral cortex. When such symptoms are caused by medications or other drugs, they are also known as extrapyramidal side effects ( EPSE ). The symptoms can be acute (short-term) or chronic (long-term).
APOE-e4 gene increases ARIA side effect risk. In addition to having an increased risk for Alzheimer’s disease, Sabalza said people with the APOE-e4 allele are also more likely to experience the ...
The second-generation iPhone SE (also known as the iPhone SE 2 or the iPhone SE 2020) is a smartphone designed, developed, and marketed by Apple Inc. It is part of the 13th generation of the iPhone, alongside the iPhone 11 and 11 Pro/Pro Max models. Apple announced it on April 15, 2020, coinciding with the discontinuation of the iPhone 8 and 8 ...
These side effects are serious and some of them are permanent, and many remain a crucial concern for companies and healthcare professionals and substantial efforts are being encouraged to reduce the potential risks for future antipsychotics through more clinical trials and drug development.