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Medical genetics. Named after. Donovan James McCune. Fuller Albright. McCune–Albright syndrome is a complex genetic disorder affecting the bone, skin and endocrine systems. It is a mosaic disease arising from somatic activating mutations in GNAS, which encodes the alpha-subunit of the G s heterotrimeric G protein. [ 1]
Hyperpigmentation can be diffuse or focal, affecting such areas as the face and the back of the hands. Melanin is produced by melanocytes at the lower layer of the epidermis. Melanin is a class of pigment responsible for producing color in the body in places such as the eyes, skin, and hair. The process of melanin synthesis (melanogenesis ...
Noonan syndrome with multiple lentigines ( NSML) which is part of a group called Ras / MAPK pathway syndromes, [2] is a rare autosomal dominant, [3] multisystem disease caused by a mutation in the protein tyrosine phosphatase, non-receptor type 11 gene ( PTPN11 ). The disease is a complex of features, mostly involving the skin, skeletal and ...
Postinflammatory hyperpigmentation ( PIH) is a skin condition characterized by the darkening of the skin ( hyperpigmentation) following an inflammatory injury, such as acne, dermatitis, infectious disease, or trauma. Less frequently, it may occur as a complication of a medical procedure performed on the skin.
Schamberg's disease, or progressive pigmented purpuric dermatosis, is a chronic discoloration of the skin which usually affects the legs and often spreads slowly. This disease is more common in males and may occur at any age from childhood onward. This condition is observed worldwide and has nothing to do with race or ethnic background.
Melasma. Melasma (also known as chloasma faciei, [ 1]: 854 or the mask of pregnancy[ 2] when present in pregnant women) is a tan or dark skin discoloration. Melasma is thought to be caused by sun exposure, genetic predisposition, hormone changes, and skin irritation. [ 3]
Seborrhoeic dermatitis. Seborrhoeic dermatitis (also spelled seborrheic dermatitis in American English) is a long-term skin disorder. [ 4] Symptoms include flaky, scaly, greasy, and occasionally itchy and inflamed skin. [ 2][ 3] Areas of the skin rich in oil -producing glands are often affected including the scalp, face, and chest. [ 4]
Roth's spots, also known as Litten spots or the Litten sign, [ 1] are non-specific red spots with white or pale centres, seen on the retina and although traditionally associated with infective endocarditis, can occur in a number of other conditions including hypertension, diabetes, collagen vascular disease, extreme hypoxia, leukemia and HIV ...