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Ames made contributions to understanding the mechanisms of mutagenesis and DNA repair. He invented the Ames test, a widely used assay for easily and cheaply evaluating the mutagenicity of compounds. [3] The test revolutionized the field of toxicology and has played a crucial role in identifying numerous environmental and industrial carcinogens.
Nitroglycerin is an example that gives a positive Ames yet is still used in treatment today. Nitrates in food however may be reduced by bacterial action to nitrites which are known to generate carcinogens by reacting with amines and amides. Long toxicology and outcome studies are needed with such compounds to disprove a positive Ames test.
The U.S. Department of Health and Human Services National Toxicology Program has declared PhIP as "reasonably anticipated to be a human carcinogen". [1] International Agency for Research on Cancer (IARC), part of World Health Organization, has classified PhIP as IARC Group 2B carcinogen (i.e., possibly carcinogenic to humans). [2]
The basic nature of cancer cells, the role of viral and chemical carcinogens, and a relationship of cancer to genes, are described. Several successful cancer therapies are examined. The 1950 Wynder and Graham Study is reviewed. The research of Bradford Hill and Richard Doll is covered with respect to chemical carcinogenesis. Bruce Ames zeros in ...
The analysis, published in the journal Frontiers in Toxicology, builds upon research published earlier this year, which identified more than 900 chemicals as being potential mammory carcinogens ...
Carcinogens – Identified chemicals that damage DNA. The Ames test was described in a series of papers in 1973 by Bruce Ames and his group at the university. Chemical elements – Sixteen elements have been discovered at Berkeley ( technetium , astatine , neptunium , plutonium , americium , curium , berkelium , californium , einsteinium ...
The World Health Organization has identified glyphosate as "possibly carcinogenic to humans" and a study published earlier this year showed that glyphosate raised the cancer risk of those exposed ...
An article by Bruce Ames in The Proceedings of the National Academy of Sciences in 2018 identified pyrroloquinoline quinone as a "longevity vitamin" not essential for immediate survival, but necessary for long-term health. [14]