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Deafness in animals can occur as either unilateral (one ear affected) or bilateral (both ears affected). This occurrence of either type of deafness seems to be relatively the same in both mixed-breed animals and pure-breed animals. [5] Research has found a significant association between deafness in dogs and the pigment genes piebald and merle ...
Veterinary oncology is a subspecialty of veterinary medicine that deals with cancer diagnosis and treatment in animals. Cancer is a major cause of death in pet animals. In one study, 45% of the dogs that reached 10 years of age or older died of cancer. [1]
Deafness can occur in white cats with yellow, green or blue irises, although it is mostly likely in white cats with blue irises. [4] In white cats with one blue eye and one eye of a different color (odd-eyed cats), deafness is more likely to affect the ear on the blue-eyed side. [1] Approximately 50% of white cats have one or two blue eyes. [5]
The inner ear sensory epithelium is highly conserved among vertebrates, which gives hope that animal models, especially mammal models such as mice, are very applicable to clinical use in humans. [33] The development of human therapies require research in human mammalian cells, perhaps inner ear epithelial organoids.
An example is sodium thiosulfate, which the US FDA approved in 2022 to minimise the risk of ototoxicity and hearing loss in newborn, child, and adolescent cancer patients receiving cisplatin. [ 29 ] [ 30 ] [ 31 ] Other agents being investigated for their potential to reduce ototoxicity include D-methionine and L-N-acetylcysteine . [ 3 ]
Schematic structures of dysferlin, myoferlin, and otoferlin; three ferlin proteins that are associated with human diseases. Lack of functional dysferlin can cause a group of muscular dystrophies knows as dysferlinopathies. Myoferlin is highly expressed in several types of cancer, and mutations in otoferlin can cause deafness.
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The Foundation for Biomedical Research (FBR) is an American nonprofit organization, 501(c)(3), located in Washington, DC.Established in 1981, the organization is dedicated to informing the news media, teachers, and other groups about the need for lab animals in medical and scientific research.