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Phase 2 study completed in 2017 and 5 year follow-up published in 2021, [30] demonstrated clear dose- and frequency-dependent improvements in cartilage thickness (primary endpoint), complete arrest in progression to joint replacement (in the high dose treatment groups), and improvements in the WOMAC pain survey for high-risk patients (secondary ...
There are several different repair options available for cartilage damage or failure. "Maci" or autologous cultured chondrocytes on porcine collagen membrane, is a treatment to correct cartilage defects in the knee. This treatment has been approved by the Food and Drug Administration in 2016 for adult treatment only. [1]
Meniscal transplantation was previously indicated for patients with mild arthritis who are younger than 50 years of age. The population for whom meniscal transplantation is appropriate has expanded. Survival data from a recent, long-term follow-up study shows that meniscal transplantation is also successful in older, arthritic patients with a ...
Osteoarthritis: Causes, Symptoms & Treatment. This article was reviewed by Craig Primack, MD, FACP, FAAP, MFOMA. Osteoarthritis is the most common form of arthritis, affecting more than 32.5 ...
Chondrocytes are the cells that make up cartilage and help maintain the extracellular matrix. In osteoarthritis, joint cartilage can become damaged, leading to movement struggles and pain in the ...
The cells targeted for the treatment of osteoarthritis are chondrocytes, synoviocytes, and their progenitors. Since the joint capsule is relatively well contained, intra-articular injections are highly successful at delivering the therapeutic gene therapy locally to the target cell types. Treatment of osteoarthritis may be successful via:
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