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Antidepressant discontinuation syndrome is a relatively new phenomenon, being identified and described from 1950s onwards, in parallel with discovery and introduction of modern antidepressant medications, with the first MAOIs, and TCAs introduced from the 1950s onwards and the first SSRIs from the 1980s onwards. [8]
Though there may be times you want to stop taking your medication, abruptly stopping SSRI treatment can result in antidepressant discontinuation syndrome, with symptoms like insomnia, mood ...
SSRI discontinuation syndrome has been reported when treatment is stopped. It includes sensory, and gastrointestinal symptoms, dizziness, lethargy, and sleep disturbances, as well as psychological symptoms such as anxiety/agitation, irritability, and poor concentration. [57] Electric shock-like sensations are typical for SSRI discontinuation. [58]
Antidepressant discontinuation syndrome, also called antidepressant withdrawal syndrome, is a condition that can occur following the interruption, reduction, or discontinuation of antidepressant medication. [187] The symptoms may include flu-like symptoms, trouble sleeping, nausea, poor balance, sensory changes, and anxiety.
SSRIs are modern antidepressants often used as a first-line treatment for major depressive disorder. Common SSRIs include Prozac (fluoxetine), Zoloft (sertraline) and Lexapro (escitalopram).
Impact of antidepressant discontinuation syndrome Joao L. de Quevedo, MD, PhD , a psychiatrist at UTHealth Houston, not involved in this research, spoke to Medical News Today about its findings.
As with SSRIs, the abrupt discontinuation of an SNRI usually leads to withdrawal, or "discontinuation syndrome", which could include states of anxiety and other symptoms. Therefore, it is recommended that users seeking to discontinue an SNRI slowly taper the dose under the supervision of a professional.
Typically, brain zaps are associated with antidepressant discontinuation syndrome (ADS), which impacts an estimated 20 percent of people who abruptly stop or reduce their use of medication.