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The Ludwig Institute for Cancer Research (LICR) maintains the "CTDatabase." [4] This database is an authoritative list of known CT antigens. It also serves as a repository into which new candidates can be entered. Important CT antigens in cancer therapy include MAGE-A1, MAGE-A3, MAGE-A4, NY-ESO-1, PRAME, CT83 and SSX2.
For cervical carcinoma patients, long antigenic peptides derived from HPV proteins were used in cancer vaccines. It was shown that relative to the corresponding 9 amino acid peptides these peptides of 30-40 amino acids were better incorporated and presented by dendritic cells , leading to improved immunogenicity .
The Cancer Genome Atlas →: National Cancer Institute, United States Copy number, Mutation, Methylation, Gene Expression, miRNA expression: Yes Yes Human: No Yes Yes CancerResource →: University Medicine Berlin, Germany Roche Cancer Genome Database (RCGDB) Roche Diagnostics, Penzberg, Germany Network of Cancer Genes →: King's College ...
Tumor antigen is an antigenic substance produced in tumor cells, i.e., it triggers an immune response in the host. Tumor antigens are useful tumor markers in identifying tumor cells with diagnostic tests and are potential candidates for use in cancer therapy. The field of cancer immunology studies such topics.
Neoepitopes are a class of major histocompatibility complex (MHC) bounded peptides. [1] They represent the antigenic determinants of neoantigens. Neoepitopes are recognized by the immune system as targets for T cells and can elicit immune response to cancer. [2] [3]
For a more simple peptide scoring tool there is a Antigen Profiler tool available that will enable you to score individual peptide sequences based upon a relation epitope mapping database of previous immunogens used to generate antibodies. Finally, as a general rule peptides should follow some basic criteria.
Cellular immunity protects the body through: T-cell mediated immunity or T-cell immunity: activating antigen-specific cytotoxic T cells that are able to induce apoptosis in body cells displaying epitopes of foreign antigen on their surface, such as virus-infected cells, cells with intracellular bacteria, and cancer cells displaying tumor antigens;
The earliest conception of PeptideAtlas began at the Institute for Systems Biology in the research lab of Ruedi Aebersold by Eric Deutsch and Sharon Chen at the Annotated Peptide Database (APD). The concept was further expanded with additional efforts from Parag Mallick and Frank Desiere.